What's in a name? Where's the person in personalized medicine?
DOI :
https://doi.org/10.20416/lsrsps.v4i2.893Mots-clés :
personalization, person, genomics, ethics, pharmacogenetics, stratificationRésumé
Medicine is said to be moving rapidly down the road towards personalization, but it is not entirely clear how we are to understand this term, or its implications for ethics. In understanding the concept of personalized medicine there are multiple possible interpretations of ‘personalization’ at stake. These may in turn presuppose different concepts of ‘person’, with resulting variations in the ethical implications.
Références
ALFIREVIC, Ana, PIRMOHAMED, Munir. 2016. Pharmacogenetics and pharmacogenomics. In KUMAR, Dhavendra, ANTONARAKIS, Stylianos (eds) Medical and Health Genomics Elsevier 121-37.
https://doi.org/10.1016/B978-0-12-420196-5.00010-1
BARRÈS, Romain. 2016. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metabolism, 23 (2), 369-78.
https://doi.org/10.1016/j.cmet.2015.11.004
CAPPS, Ben, CHADWICK, Ruth (Chair), CHALMERS, Don, CLARKE, Angus, CLAYTON, Ellen, LIU, Ed (President of HUGO, Co-chair), LYSAGHT, Tamra, MULVIHILL John, WINSLETT, Marianne. 2013. Imagined Futures: Capturing the Benefits of Genome Sequencing for Society. Report prepared by the working group of the HUGO Committee on Ethics, Law and Society.
http://www.hugo-international.org/Resources/Documents/CELS_Article-ImaginedFutures_2014.pdf
CHADWICK, Ruth. 2014. The ethics of personalized medicine: a philosopher’s perspective. Personalized Medicine, 11 (1), 5-6.
https://doi.org/10.2217/pme.13.98
CHADWICK, Ruth, O’CONNOR, Alan. 2013. Epigenetics and personalized medicine: prospects and ethical issues. Personalized Medicine, 10 (5), 463-71.
https://doi.org/10.2217/pme.13.35
CHIAPPERINO, Luca, TESTA, Giuseppe. 2016. The epigenomic self in personalized medicine: between responsibility and empowerment. The Sociological Review Monographs, 64 (1), 203-20.
https://doi.org/10.1002/2059-7932.12021
DAAR, Abdallah, SINGER, Peter. 2005. Pharmacogenomics and geographical ancestry: implications for drug development and global health, Nature Reviews Genetics, 6 (3), 241-6.
https://doi.org/10.1038/nrg1559
UK DEPARTMENT OF HEALTH 2003. Our Inheritance Our Future: Realising the potential of genetics in the NHS. London: Department of Health [Cm5791].
DYSON, Freeman. 2016. Is life analog or digital? Edge.
https://www.edge.org/conversation/freeman_dyson-is-life-analog-or-digital (Accessed on 1 December 2016)
EUROPEAN COMMISSION. 2016. Personalised medicine: background, conference reports, publications and links related to personalized medicine. https://ec.europa.eu/research/health/index.cfm?pg=policy&policyname=personalised (Accessed on 5 December 2016)
FLORIDI, Luciano. 2011. The Philosophy of Information. Oxford : University Press.
HEDGECOE, Adam. 2004. The Politics of Personalised Medicine: Pharmacogenetics in the Clinic. Cambridge: University Press.
https://doi.org/10.1017/CBO9780511489136
HESSLER, Kristen. 2013. Epigenetic inheritance andhe moral responsibilities of mothers. Virtual Mentor, 15 (9), 767-70.
https://doi.org/10.1001/virtualmentor.2013.15.9.stas1-1309
HEUSSER, Peter. 2015. Towards integration of ‘personalized’ and ‘person-centred medicine: the concept of ‘integrative and personalized health care. In VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan (eds). The Ethics of Personalised Medicine: Critical Perspectives. Farnham: Ashgate. 77-83.
JUENGST, Eric, McGOWAN, Michelle, FISHMAN, Jennifer, SETTERSTEIN, Richard. 2016. From “personalized” to “precision” medicine: the ethical and social implications of rhetorical reform in genomic medicine. Hastings Center Report, 46 (5), 21-33.
https://doi.org/10.1002/hast.614
LANCET. 2017. Editorial: Precision global health: beyond prevention and control. The Lancet Global Health, 5 (1), e1.
https://doi.org/10.1016/S2214-109X(16)30339-4
PRAINSACK, Barbara. 2014. Personhood and solidarity: what kind of personalized medicine do we want?. Personalized Medicine, 11 (7), 651-7.
https://doi.org/10.2217/pme.14.49
PRAINSACK, Barbara. 2015. Through thick and big: data-rich medicine in the era of personalization. In The Ethics of Personalised Medicine. Farnham: Ashgate. 161-72.
RUTKIN, Aviva. 2014. Off the clock, on the record. New Scientist, 224 (2991), 22-3.
https://doi.org/10.1016/S0262-4079(14)61997-7
SCHLEIDGEN, Sebastian, KLINGLER, Corinna, BERTRAM, Teresa, ROGOWSKI, Wolf, MARCKMANN, Georg. 2015. What is personalized medicine? Sharpening a vague term based on a systematic literature review. In VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan. (eds). The Ethics of Personalised Medicine: Critical Perspectives. Farnham: Ashgate. 9 -24.
SCHORK, Nicholas. 2015. Personalized medicine: time for one-person trials. Nature, 520 (7549), 609-11.
https://doi.org/10.1038/520609a
SNYDER. Michael. 2016. Personalized Medicine: What Everyone Needs to Know. Oxford: University Press.
THALER, Richard, SUNSTEIN, Cass. 2008. Nudge: Improving Decisions and Health, Wealth and Happiness. New Haven: Yale University Press.
TUTTON, Richard. 2014. Genomics and the Reimagining of Personalized Medicine. Farnham: Ashgate.
VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan. (eds). 2015. The Ethics of Personalized Medicine: Critical Perspectives. Farnham: Ashgate.
WHITE HOUSE. 2016. The Precision Medicine Initiative. https://obamawhitehouse.archives.gov/node/333101 (Accessed on 15 July 2017).
WÖHLKE, Sabine, PERRY, Julie, SCHICKTANZ, Silke. 2015. ’Taking it personally: patients’ perspectives on personalized medicine and its ethical relevance. In VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan (eds). The Ethics of Personalised Medicine: Critical Perspectives. Farnham: Ashgate. 129-47.
WONG, Ada Hang, DENG, Chuxia. 2015. Precision medicine for personalized cancer therapy. International Journal of Biological Sciences. 11 (12), 1410-2.
https://doi.org/10.1016/B978-0-12-420196-5.00010-1
BARRÈS, Romain. 2016. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metabolism, 23 (2), 369-78.
https://doi.org/10.1016/j.cmet.2015.11.004
CAPPS, Ben, CHADWICK, Ruth (Chair), CHALMERS, Don, CLARKE, Angus, CLAYTON, Ellen, LIU, Ed (President of HUGO, Co-chair), LYSAGHT, Tamra, MULVIHILL John, WINSLETT, Marianne. 2013. Imagined Futures: Capturing the Benefits of Genome Sequencing for Society. Report prepared by the working group of the HUGO Committee on Ethics, Law and Society.
http://www.hugo-international.org/Resources/Documents/CELS_Article-ImaginedFutures_2014.pdf
CHADWICK, Ruth. 2014. The ethics of personalized medicine: a philosopher’s perspective. Personalized Medicine, 11 (1), 5-6.
https://doi.org/10.2217/pme.13.98
CHADWICK, Ruth, O’CONNOR, Alan. 2013. Epigenetics and personalized medicine: prospects and ethical issues. Personalized Medicine, 10 (5), 463-71.
https://doi.org/10.2217/pme.13.35
CHIAPPERINO, Luca, TESTA, Giuseppe. 2016. The epigenomic self in personalized medicine: between responsibility and empowerment. The Sociological Review Monographs, 64 (1), 203-20.
https://doi.org/10.1002/2059-7932.12021
DAAR, Abdallah, SINGER, Peter. 2005. Pharmacogenomics and geographical ancestry: implications for drug development and global health, Nature Reviews Genetics, 6 (3), 241-6.
https://doi.org/10.1038/nrg1559
UK DEPARTMENT OF HEALTH 2003. Our Inheritance Our Future: Realising the potential of genetics in the NHS. London: Department of Health [Cm5791].
DYSON, Freeman. 2016. Is life analog or digital? Edge.
https://www.edge.org/conversation/freeman_dyson-is-life-analog-or-digital (Accessed on 1 December 2016)
EUROPEAN COMMISSION. 2016. Personalised medicine: background, conference reports, publications and links related to personalized medicine. https://ec.europa.eu/research/health/index.cfm?pg=policy&policyname=personalised (Accessed on 5 December 2016)
FLORIDI, Luciano. 2011. The Philosophy of Information. Oxford : University Press.
HEDGECOE, Adam. 2004. The Politics of Personalised Medicine: Pharmacogenetics in the Clinic. Cambridge: University Press.
https://doi.org/10.1017/CBO9780511489136
HESSLER, Kristen. 2013. Epigenetic inheritance andhe moral responsibilities of mothers. Virtual Mentor, 15 (9), 767-70.
https://doi.org/10.1001/virtualmentor.2013.15.9.stas1-1309
HEUSSER, Peter. 2015. Towards integration of ‘personalized’ and ‘person-centred medicine: the concept of ‘integrative and personalized health care. In VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan (eds). The Ethics of Personalised Medicine: Critical Perspectives. Farnham: Ashgate. 77-83.
JUENGST, Eric, McGOWAN, Michelle, FISHMAN, Jennifer, SETTERSTEIN, Richard. 2016. From “personalized” to “precision” medicine: the ethical and social implications of rhetorical reform in genomic medicine. Hastings Center Report, 46 (5), 21-33.
https://doi.org/10.1002/hast.614
LANCET. 2017. Editorial: Precision global health: beyond prevention and control. The Lancet Global Health, 5 (1), e1.
https://doi.org/10.1016/S2214-109X(16)30339-4
PRAINSACK, Barbara. 2014. Personhood and solidarity: what kind of personalized medicine do we want?. Personalized Medicine, 11 (7), 651-7.
https://doi.org/10.2217/pme.14.49
PRAINSACK, Barbara. 2015. Through thick and big: data-rich medicine in the era of personalization. In The Ethics of Personalised Medicine. Farnham: Ashgate. 161-72.
RUTKIN, Aviva. 2014. Off the clock, on the record. New Scientist, 224 (2991), 22-3.
https://doi.org/10.1016/S0262-4079(14)61997-7
SCHLEIDGEN, Sebastian, KLINGLER, Corinna, BERTRAM, Teresa, ROGOWSKI, Wolf, MARCKMANN, Georg. 2015. What is personalized medicine? Sharpening a vague term based on a systematic literature review. In VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan. (eds). The Ethics of Personalised Medicine: Critical Perspectives. Farnham: Ashgate. 9 -24.
SCHORK, Nicholas. 2015. Personalized medicine: time for one-person trials. Nature, 520 (7549), 609-11.
https://doi.org/10.1038/520609a
SNYDER. Michael. 2016. Personalized Medicine: What Everyone Needs to Know. Oxford: University Press.
THALER, Richard, SUNSTEIN, Cass. 2008. Nudge: Improving Decisions and Health, Wealth and Happiness. New Haven: Yale University Press.
TUTTON, Richard. 2014. Genomics and the Reimagining of Personalized Medicine. Farnham: Ashgate.
VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan. (eds). 2015. The Ethics of Personalized Medicine: Critical Perspectives. Farnham: Ashgate.
WHITE HOUSE. 2016. The Precision Medicine Initiative. https://obamawhitehouse.archives.gov/node/333101 (Accessed on 15 July 2017).
WÖHLKE, Sabine, PERRY, Julie, SCHICKTANZ, Silke. 2015. ’Taking it personally: patients’ perspectives on personalized medicine and its ethical relevance. In VOLLMAN, Jochen, SANDOW, Verena, WÄSCHER, Sebastian, SCHILDMANN, Jan (eds). The Ethics of Personalised Medicine: Critical Perspectives. Farnham: Ashgate. 129-47.
WONG, Ada Hang, DENG, Chuxia. 2015. Precision medicine for personalized cancer therapy. International Journal of Biological Sciences. 11 (12), 1410-2.
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Publiée
2018-03-27
Comment citer
Chadwick, Ruth Felicity. 2018. « What’s in a Name? Where’s the Person in Personalized Medicine? ». Lato Sensu: Revue De La Société De Philosophie Des Sciences 4 (2). https://doi.org/10.20416/lsrsps.v4i2.893.
Numéro
Rubrique
Les enjeux contemporains de la médecine personnalisée
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Ce travail est disponible sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
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