PO-009 Exercise Adaptation of Skeletal Muscle Fibers: The Role of MicroRNAs

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  • Jian Shou Shanghai university of sport
  • Peijie Chen Shanghai university of sport
  • Weihua Xiao Shanghai university of sport


Objective Explore the relationship between exercise adaptation of skeletal muscle fibers and microRNAs.

Methods Research related papers.

Results endurance training can switch muscle fiber type by promoting microRNAs (miR-208b, miR-499). For example, the conversion from fast Type IIb muscle fibers to slower Type IIx/d muscle fibers, or from Type IIx muscle fibers to Type IIa muscle fibers. Endurance training can also promote the expression of Peroxisome Proliferator Receptor Gamma Coactivator-1α (PGC-1α) and enhance the oxidative potential for slow muscle fibers by inhibiting some microRNAs such as miR-23a. Resistance training can activate insulin-like growth factor-1/phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin/P70 ribosomal protein S6 kinase (IGF-1/PI3K/Akt/mTOR/P70S6K) pathways and promote fast muscle fibers hypertrophy by inhibiting negative microRNAs (miR-1,miR-133,miR-128a) and promoting positive microRNAs (miR-27,miR-29,miR-486).

Conclusions MicroRNAs play an important role in the exercise adaptation of skeletal muscle fibers.