Maxillofacial bone diseases represent a heterogeneous group involving benign and malign tumors, and metabolic, malformative, and infectious diseases. They have a tendency to relapse even with a good initial treatment. Therefore, we need to start with active surveillance based on medical imaging (CT scanner). The treatment of maxillofacial bone diseases is based mainly on clinical examination, radiological findings, and pathological diagnosis. The treatment consists of curettage or maxillary/mandibulary interruptive or not-interruptive bone resection. Development of guidelines seems impossible due to the heterogenicity of clinical presentations. The individualized treatment should prevail.